Now showing items 1-3 of 3
Two reduction methods to simplify complex ODE mathematical models of biological networks and a case study: The G1/S checkpoint/DNA-damage signal transduction pathways
(Lincoln University, 2018-07-25)
Model reduction is a hot topic in studies of biological systems. By reducing the complexity of detailed models through finding important elements, developing multi-level models and keeping the soul (biological meaning) of ...
Holistic complex systems modelling approaches for cell signalling networks – Mammalian cell cycle control system
(Lincoln University, 2019)
Cell cycle is a precisely regulated process in which cells of living organisms go through a sophisticated growth and division cycle that eventually leads to production of two daughter cells (Morgan, 2007; Satyanarayana & ...
Investigation of robustness and dynamic behaviour of G1/S checkpoint/DNA-damage signal transduction pathway based on mathematical modelling and a novel neural network approach
(Lincoln University, 2011)
The control of cell cycle checkpoints in cell cycle regulation is an extremely important function in living organisms. Mutation of the checkpoint regulators can cause gene or chromosome instability, which eventually results ...