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An association between lifespan and variation in insulin-like growth factor I receptor in sheep

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Show simple item record Byun, Seung O. en Forrest, Rachel en Frampton, Christopher M. en Zhou, Huitong en Hickford, Jonathan G. H. en 2017-09-08T03:41:46Z 2015-01-20 en 2012 en 2011-10-16 en
dc.identifier.citation Byun, S., Forrest, R. H., Frampton, C. M., Zhou, H. & Hickford, J. (2012). An association between lifespan and variation in insulin-like growth factor I receptor in sheep. Journal of Animal Science, 90(8), pp. 2484-2487. doi: 10.2527/jas.2011-4148. en
dc.identifier.issn 0021-8812 en
dc.description.abstract Longevity in livestock is a valuable trait. When productive animals live longer, fewer replacement animals need to be raised. However, selection for longevity is not commonly the focus of breeding programs as direct selection for long-lived breeding stock is virtually impossible until late in the reproductive life of the animal. Additionally the underlying genetic factors or genes associated with longevity are either not known, or not well understood. In humans, there is evidence that IGF 1 receptor (IGF1R) is involved in longevity. Polymorphism in the IGF1R gene has been associated with longevity in a number of species. Recently, 3 alleles of ovine IGF1R were identified, but no analysis of the effect of IGF1R variation on sheep longevity has been reported. In this study, associations between ovine IGF1R variation, longevity and fertility were investigated. Polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) was used to type IGF1R variation in 1,716 New Zealand sheep belonging to 6 breeds and 36 flocks. Ovine IGF1R C was associated with age when adjusting for flock (present 5.5 ± 0.2 yr, absent 5.0 ± 0.1 yr, P = 0.02). A general linear mixed effects model suggested an association (P = 0.06) between age and genotype, when correcting for flock. Pairwise comparison (least significant difference) of specific genotypes revealed the difference to be between AA (5.0± 0.1 yr) and AC (5.6 ± 0.2 yr, P = 0.02). A weak negative Pearson correlation between fertility and longevity traits was observed (r = -0.25, P < 0.01). The finding of an association between variation in IGF1R and lifespan in sheep may be useful in prolonging the lifespan of sheep. en
dc.format.extent 2484-2487 en
dc.language.iso en en
dc.publisher American Society of Animal Science en
dc.relation The original publication is available from - American Society of Animal Science - en
dc.relation.uri en
dc.rights © 2012 American Society of Animal Science. All rights reserved. en
dc.subject fertility en
dc.subject insulin-like growth factor 1 en
dc.subject longevity en
dc.subject polymerase chain reaction-single strand conformational polymorphism en
dc.subject sheep en
dc.subject.mesh Animals en
dc.subject.mesh Receptor, IGF Type 1 en
dc.subject.mesh Gene Expression Regulation en
dc.subject.mesh Genotype en
dc.subject.mesh Female en
dc.subject.mesh Genetic Variation en
dc.title An association between lifespan and variation in insulin-like growth factor I receptor in sheep en
dc.title.alternative An association between lifespan and variation in IGF1R in sheep en
dc.type Journal Article
lu.contributor.unit Lincoln University en
lu.contributor.unit Faculty of Agriculture and Life Sciences en
lu.contributor.unit Department of Agricultural Sciences en
lu.contributor.unit Research Management Office en
lu.contributor.unit /LU/Research Management Office/2018 PBRF Staff group en
dc.identifier.doi en
dc.subject.anzsrc 0604 Genetics en
dc.subject.anzsrc 0702 Animal Production en
dc.subject.anzsrc 060405 Gene Expression (Incl. Microarray and Other Genome-Wide Approaches) en
dc.relation.isPartOf Journal of Animal Science en
pubs.issue 8 en
pubs.organisational-group /LU
pubs.organisational-group /LU/Agriculture and Life Sciences
pubs.organisational-group /LU/Agriculture and Life Sciences/AGSC
pubs.organisational-group /LU/Research Management Office
pubs.organisational-group /LU/Research Management Office/2018 PBRF Staff group
pubs.publication-status Published en
pubs.volume 90 en USA en
lu.identifier.orcid 0000-0001-9313-761X
lu.identifier.orcid 0000-0001-7620-3160

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